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KMID : 0370019990130000061
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Chung-Ang Journal of Pharmacal Sciences
1999 Volume.13 No. 0 p.61 ~ p.73
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The Antiplatelet Aggregating Effect of a Derivative of Ginkgolide B, SKI 5051, in vitro and in vivo
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Abstract
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This study was performed to test the antiplatelet aggregating effect of a derivative of Ginkgolide B(SKI 5051) alone and with calcium antagonist and aspirin on the mouse pulmonary thromboembolism and collagen-induced rabbit platelet aggregation.
Ginkgolide B is a potent PAF antagonist, which was isolated from the leaves of Ginkgo biloba and 10´ -(3,5-Dimethylpyridine-2-methoxy) Ginkgolide B(SKI 5051) is a derivative of Ginkgokide B.
A derivative of Ginkgolide B(SKI 5051) protected mice from sudden death by collagen and epinephrine mixture and inhibited collagen-induced rabbit platelet aggregation dose-dependently. These effects increased by concurrent administration with aspirin and verapamil.
These results suggest that a derivative of Ginkgolide B(SKI 5051) is a effective drug for preventing disease associated with platelet aggregation and this effect is increased by concurrent administration with calcium antagonist and aspirin.
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